Below is an approximation of this video’s audio content material. To see any graphs, charts, graphics, photos, and quotes to which Dr. Greger could also be referring, watch the above video.
“Metastasis is the leading cause of cancer-[related death].” Cancer kills, as a result of most cancers spreads. For instance, the five-year survival price for women with localized breast most cancers is almost 99 p.c, however that drops to simply 27 p.c in these with metastasized most cancers. Yet “our ability to eﬀectively treat metastatic disease has not changed signiﬁcantly in the past few decades.” You know issues are getting determined when there are papers like this: “Targeting Metastasis with Snake Toxins.”
Now, we do have built-in defenses––pure killer cells that roam the body killing off budding tumors, and I’ve movies on boosting pure killer cell exercise. But as I defined within the final video, there’s a fats receptor referred to as CD36 that seems to be essential for most cancers cells to unfold, and these most cancers cells reply to dietary fats consumption. But not all fats.
CD36 is upregulated by palmitic acid, as a lot as a 50-fold improve inside 12 hours. Palmitic acid is a saturated fats present in junk food created from palm oil, however it’s most concentrated in meat and dairy. This could clarify why, for those who have a look at “dietary fat and breast cancer mortality,” there was no distinction in danger of breast-cancer-speciﬁc loss of life for women within the highest versus lowest class of complete fats consumption. But, you’re about 50 p.c extra doubtless to die of breast most cancers for those who eat lots of saturated fats. The systematic evaluate and “…meta-analyses [conclude]… that saturated fat intake negatively impacts upon breast cancer survival.”
This could clarify why “intake of high-fat dairy, but not low-fat dairy, was related to a higher risk of mortality after breast cancer diagnosis.” If it was the dairy protein, like casein, that was an issue; the skim milk is perhaps even worse. But no, it was the saturated butterfat, possibly as a result of it triggered that CD36-induced cancer-spreading mechanism. “…Women who consumed one or more servings per day of high-fat dairy had … [about a 50] percent higher risk of dying from breast cancer.”
We see the identical factor with “dairy intake in relation to prostate cancer survival.” “…Drinking high-fat milk [appeared to increase] the risk of dying from prostate cancer by as much as 600 percent in patients with localized prostate cancer,” however “low-fat milk was not associated with such an increase in risk.” So, it appeared to be the animal fats, relatively than the animal protein, and that is constant with what Harvard researchers discovered within the United States.
More proof that the fats receptor CD36 is concerned is “…that the risk of colorectal cancer for meat consumption increased from [just doubling risk to octupling risk]”—multiplying the percentages of getting most cancers eight-fold for individuals who carry a selected kind of CD36 gene. So, “Is It Time to Give Breast Cancer Patients a Prescription for a Low-Fat Diet?” A most cancers prognosis is a “teachable moment” if there ever was one to inspire individuals to make adjustments to their way of life. But provision of evidence-based pointers is essential, and also you don’t know, till you set it to the check.
“A randomized, prospective, multicenter clinical trial to test the effect of a dietary intervention designed to reduce fat intake in women with resected, early-stage breast cancer…” (which means the women had their breast most cancers surgically eliminated and have been praying it doesn’t come again). The dietary intervention group dropped their fats consumption from about 30 p.c of energy down to 20 p.c of energy, dropping saturated fats consumption about 40 p.c, and maintained that 40-percent decrease consumption after one yr, three years, 5 years. And… “after approximately five years of follow-up, [the] women in the dietary intervention group had a 24-percent lower risk of relapse…”, a 24-percent decrease danger of the most cancers coming again.
That was the WINS research, the Women’s Intervention Nutrition Study. Then there was the Women’s Health Initiative research, the place once more, women have been randomized to drop their fats consumption down to about 20 p.c of energy, and once more, these within the dietary intervention group skilled elevated breast most cancers survival, which means “a dietary change may be able to influence breast cancer outcome[s].” And not solely was breast most cancers survival considerably better; the women additionally skilled a discount in coronary heart illness and a discount in diabetes as just a little aspect bonus.
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